claustrum
Consciousness Science at the Crossroads: From the Hard Problem to the Engineering Era
In 1994, David Chalmers stood before an audience at the first Tucson conference on consciousness and articulated what he called the "hard problem" — why does subjective experience exist at all? Why is there something it is like to see red, feel pain, taste coffee?
Orchestrated Objective Reduction Gets Its Strongest Experimental Backing
For three decades, the Orchestrated Objective Reduction (Orch OR) theory of consciousness has occupied a peculiar position in science: simultaneously the most ambitious and most ridiculed theory in the field. Proposed by Nobel laureate physicist Roger Penrose and anesthesiologist Stuart Hameroff...
Ten Mind-Blowing Brain Discoveries of 2025: A Synthesis
The year 2025 may be remembered as the year consciousness science crossed from philosophical speculation into engineering-grade empirical investigation. Inspired by Scientific American's tradition of year-end discovery roundups, this synthesis examines the ten most consequential brain and...
Transcranial Focused Ultrasound: The New Scalpel for Consciousness Research
For decades, consciousness researchers faced an engineering bottleneck that no amount of theoretical brilliance could solve: they could not precisely stimulate deep brain structures without cutting open the skull. Surface-level tools like transcranial magnetic stimulation (TMS) and transcranial...
The Neuroscience of Psychedelics
The scientific study of psychedelic compounds has undergone a remarkable renaissance since the early 2010s, producing some of the most significant advances in our understanding of consciousness, neural connectivity, and brain plasticity in modern neuroscience. Classic psychedelics — psilocybin,...
Psilocybin and the 5-HT2A Receptor: How One Receptor Creates the Entire Psychedelic Experience
Of the fourteen serotonin receptor subtypes distributed across the human brain, one stands apart. One receptor, when activated by the right molecular key, produces the most profound alteration of consciousness available through pharmacology: ego dissolution, visual hallucinations, synesthesia,...