ketamine
Psychedelic-Assisted Therapy for Addiction
The use of psychedelic substances for treating addiction is simultaneously one of the oldest therapeutic practices in human history and one of the most promising frontiers of modern psychiatry. Indigenous cultures have used ayahuasca, peyote, iboga, and psilocybin mushrooms for healing addiction...
Orchestrated Objective Reduction Gets Its Strongest Experimental Backing
For three decades, the Orchestrated Objective Reduction (Orch OR) theory of consciousness has occupied a peculiar position in science: simultaneously the most ambitious and most ridiculed theory in the field. Proposed by Nobel laureate physicist Roger Penrose and anesthesiologist Stuart Hameroff...
Psychedelic Neuroplasticity Breakthroughs: The Fastest Brain Rewiring Ever Observed
By 2025, the scientific evidence has become overwhelming: psychedelic compounds are the most powerful neuroplasticity inducers ever discovered. A single dose of psilocybin produces structural brain changes — new dendritic spines, new synaptic connections, reorganized neural networks — within 24...
Psychedelics for Disorders of Consciousness: Can You Reboot a Brain?
Here is the question that sits at the intersection of psychedelic science, consciousness research, and critical care medicine: if psychedelics are the most powerful known tools for increasing brain complexity, connectivity, and plasticity in healthy brains, can they restore consciousness in...
Near-Death Experiences and Shamanic Initiation: When Clinical Death Meets Ancient Ceremony
Here is something that should stop you mid-step: a Dutch cardiologist and a Siberian shaman, separated by five thousand miles and five thousand years of cultural context, are describing the same journey. One speaks in the language of peer-reviewed cardiology journals.
Psychedelics and Neuroplasticity: How Psilocybin, Ayahuasca, and DMT Rebuild the Brain
For most of the twentieth century, neuroscience operated under a grim assumption: the adult brain was essentially fixed. Once the critical periods of childhood development closed, the brain's wiring was set.
Near-Death Experiences: What Clinical Data Reveals About Consciousness and Brain Death
The near-death experience (NDE) is one of the most well-documented anomalies in clinical medicine — and one of the most systematically ignored. Approximately 10-20% of people who survive cardiac arrest report detailed, vivid experiences during the period when their brain showed no measurable...
Iboga and the Bwiti Tradition: The Root That Breaks Addiction and Opens the Door to the Ancestors
In the equatorial rainforests of Central Africa — Gabon, Cameroon, and the Republic of Congo — a small understory shrub with yellow flowers and orange fruit grows in the shade of the forest canopy. Tabernanthe iboga is not impressive to look at.
BDNF: Miracle-Gro for the Brain — How Movement Builds New Consciousness Hardware
There is a molecule in your brain that determines whether you grow new neurons or lose them. It determines whether your synapses strengthen or wither.
The Flow Genome Project: Mapping Ecstasis Across Navy SEALs, Silicon Valley, and Extreme Athletes
Something happened in American high-performance culture in the early 21st century that few people noticed until Steven Kotler and Jamie Wheal documented it. Across seemingly unrelated domains — the military, Silicon Valley, extreme sports, and the psychedelic underground — elite performers had...
John C. Lilly and the Isolation Tank: The Most Radical Consciousness Researcher of the 20th Century
In 1954, at the National Institute of Mental Health (NIMH) in Bethesda, Maryland, a neuroscientist named John Cunningham Lilly designed and built the first isolation tank. The prevailing scientific question of the era was whether consciousness required external sensory stimulation to maintain...
Magnesium Absorption in the Float Tank: A Consciousness-Enhancing Mineral Therapy
Every float tank contains approximately 1,000 pounds of Epsom salt — magnesium sulfate (MgSO4) — dissolved in roughly 200 gallons of water. This concentration, approximately 25% by weight, creates a solution so dense that the human body floats effortlessly on the surface, like a cork in the Dead...
Complicated Grief and Prolonged Grief Disorder
Most bereaved individuals, despite the intensity of their suffering, gradually adapt to loss through a natural process of oscillation between grief and restoration. For approximately 7-10% of bereaved adults, however, grief becomes a chronic, debilitating condition that does not follow the...
Chronic Pain: Rewiring the Pain System
Acute pain is a gift. It tells you to pull your hand from the fire, to stop walking on a broken ankle, to rest after surgery.
Men's Mental Health: Breaking the Silence
Men build fortresses. Emotional walls, stoic facades, the quiet agreement to never talk about what hurts.
PTSD & Trauma: The Functional Medicine Approach
Trauma is not a psychological event. It is a full-body recalibration — a rewiring of the nervous system that changes how you breathe, digest, sleep, and relate to other humans.
Rapamycin and mTOR: The Master Switch Between Growth and Longevity
In 1964, a Canadian medical expedition collected soil samples from Rapa Nui — Easter Island — hoping to find new antibiotics. What they found instead was a molecule that would become the most important drug in longevity research.
Clinical Medicine — Diagnosis & Treatment
A: Most likely diagnosis is Type 2 Diabetes Mellitus.
Emergency Medicine & Trauma Management Training Data
START triage is designed for mass casualty incidents. Every patient arriving at the clinic during an emergency should be rapidly categorized:
Pharmacology & Medication
A:
Pharmacy Supply Management Training Data
- Adult Dose: 500-1000 mg PO/IV Q4-6H, max 3-4 g/day (3 g/day if >65 yr) - Pediatric Dose: 15 mg/kg PO Q4-6H, max 5 doses/day; <2 yr: 10-15 mg/kg - Route: PO, IV, rectal - Frequency: Q4-6H - Max Daily Dose: 3-4 g - Major SE: Hepatotoxicity at overdose, rash, nausea - Contraindications: Severe...
Comprehensive Surgical Training Data
Aseptic technique prevents surgical site infections (SSIs) through elimination of microorganisms from the surgical field. Key principles: (1) sterilization of instruments/equipment, (2) sterile field maintenance, (3) preventing microbial contamination, (4) limiting environmental shedding.
Stanislav Grof's Perinatal Matrices: How Birth Imprints the Architecture of Consciousness
Stanislav Grof is arguably the most important consciousness researcher of the twentieth century, and certainly the most controversial. A Czech-born psychiatrist who conducted over 4,000 LSD-assisted psychotherapy sessions between 1956 and 1967 (when LSD was still a legal research tool) at the...
Critical Period Reopening: Psychedelics as Time Machines for the Brain
In June 2023, Gul Dolen's laboratory at Johns Hopkins University published a paper in Nature that may be the most important discovery in psychedelic science in a decade: psychedelic compounds reopen critical periods of social learning in adult mice. Critical periods are time-limited...
Ibogaine and Addiction Interruption
Ibogaine is an indole alkaloid derived from the root bark of Tabernanthe iboga, a shrub native to the rainforests of Central West Africa, particularly Gabon and Cameroon. Among all psychedelic compounds, ibogaine occupies the most unusual pharmacological and therapeutic position: it acts...
Ketamine and Dissociative Therapy
Ketamine, a dissociative anesthetic developed in 1962 by Calvin Stevens at Parke-Davis and first used clinically in 1970, has undergone a remarkable transformation from battlefield anesthetic to the first truly novel antidepressant mechanism in over half a century. Its rapid-acting...
Ketamine: The Anesthesiologist's Psychedelic and the Fastest Antidepressant Known
In the landscape of psychiatric pharmacology, ketamine stands as an anomaly that rewrote the rules. For fifty years, the dominant theory of depression held that it resulted from a deficiency of monoamine neurotransmitters — primarily serotonin.
The Neuroscience of Psychedelics
The scientific study of psychedelic compounds has undergone a remarkable renaissance since the early 2010s, producing some of the most significant advances in our understanding of consciousness, neural connectivity, and brain plasticity in modern neuroscience. Classic psychedelics — psilocybin,...
Non-Hallucinogenic Psychoplastogens: Neuroplasticity Without the Trip
What if you could get the brain-rewiring benefits of a psychedelic without the 6-8 hour journey into altered consciousness? What if the neuroplasticity — the new dendrites, new synapses, new connections that make psychedelics the most powerful brain restructuring tools ever discovered — could be...
The Psychedelic Renaissance in 2025: A Complete Map of the Field
The psychedelic renaissance — the resurgence of scientific and clinical interest in psychedelic compounds after decades of prohibition — has by 2025 matured from a fringe movement into a legitimate biomedical field with billion-dollar valuations, FDA breakthrough therapy designations, published...
REBUS and the Entropic Brain: How Psychedelics Rewrite Reality
In 2019, Robin Carhart-Harris and Karl Friston published what has become the most influential theoretical paper in psychedelic science: "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" in Pharmacological Reviews. The paper synthesizes two frameworks —...
Modern Sacred Spaces: Designing Environments That Elevate Consciousness
Every culture in human history built spaces specifically designed to alter consciousness. The pyramid, the cathedral, the temple, the kiva, the longhouse, the sweat lodge — these are not merely buildings where spiritual practices happen to take place.
Psychedelic-Assisted Therapy: A Clinical Framework
After four decades of prohibition, psychedelic substances are returning to clinical medicine — not as counterculture relics but as the most significant breakthrough in psychiatric treatment since the development of SSRIs. The research is emerging from the world's most rigorous institutions —...
Psychosis vs. Mystical Experience: When the Boundary Dissolves
A man sits in a psychiatric ward, convinced that he is at the center of a cosmic event, that reality has revealed its true nature to him, that he can perceive dimensions of existence that others cannot see. He speaks in a pressured, fragmented way about the interconnectedness of all things,...
Neuroplasticity and Trauma Recovery: How the Brain Rewires After Devastation
For most of the twentieth century, neuroscience operated under a doctrine that now seems almost comically wrong: the adult brain was fixed. After a critical period in childhood, the brain was believed to be hardwired — its circuits set, its structure finalized, its capacity for change...
Trauma Resolution: The Complete Medicine Protocol for Consciousness Restoration
After decades of research — from van der Kolk's neuroimaging to Porges' polyvagal theory, from Levine's somatic observations to Yehuda's epigenetics — a comprehensive picture of trauma has emerged that transcends any single theoretical framework. Trauma is not primarily a psychological problem,...
Vagus Nerve Stimulation: The Body's Master Reset Button
Cranial nerve X — the vagus nerve — is the longest and most complex cranial nerve in the human body. Its Latin name means "wanderer," and it wanders extensively: from the brainstem through the neck, chest, and abdomen, innervating the heart, lungs, stomach, intestines, liver, spleen, kidneys,...