tryptamine
Melatonin: Far More Than a Sleep Molecule
Melatonin has been reduced in the popular imagination to a sleep supplement — a molecule you buy at the drugstore when jet lag disrupts your schedule. This trivialization obscures what may be the most multifunctional molecule in human biology.
The DMT-Pineal Connection: The Spirit Molecule Meets the Third Eye
In 2000, a psychiatrist named Rick Strassman published a book called "DMT: The Spirit Molecule" that would ignite one of the most fascinating -- and contentious -- debates in modern neuroscience. The book described his groundbreaking clinical research at the University of New Mexico, where he...
DMT and the Chemistry of Dying: The Endogenous Psychedelic at the Threshold of Death
In 1990, Rick Strassman, a psychiatrist at the University of New Mexico, received the first federal approval in over 20 years to administer a psychedelic compound to human subjects. The compound was N,N-dimethyltryptamine — DMT — a molecule so potent that it produces a complete transformation of...
R. Gordon Wasson: The Banker Who Rediscovered Psychedelic Mushrooms and Launched a Revolution
On the night of June 29, 1955, in a small Mazatec village in the mountains of Oaxaca, Mexico, a 57-year-old vice president of J.P. Morgan & Co.
Soma and Haoma: The Divine Plant That Built Two Civilizations and Then Vanished
In the oldest sacred text of the Indo-European world — the Rigveda, composed between approximately 1500 and 1200 BCE — 120 hymns are dedicated to a single substance. Not a god in the conventional sense, though it is addressed as a deity.
Egyptian Sacred Science: Temple Consciousness, the Eye of Horus, and the Geometry of Awakening
Modern tourists walk through Egyptian temples as they walk through museums — admiring the scale, photographing the columns, glancing at the hieroglyphs they cannot read. They are walking through the most sophisticated consciousness technology ever built in stone, and they do not know it.
Endogenous DMT and Mystical States: When the Body Produces Its Own Spirit Molecule
N,N-Dimethyltryptamine — DMT — is the most powerful psychedelic compound known to science. When administered intravenously, it produces within seconds an experience that participants consistently describe as the most intense, most profound, and most "real-feeling" event of their lives.
Light Fasting and Darkness Retreats: How the Absence of Light Activates the Brain's Inner Pharmacy
Every article in this collection describes what light does to the body — how photons charge mitochondria, synthesize vitamin D, set circadian clocks, release nitric oxide, and power the neurochemical pipelines of consciousness. But there is a complementary practice, known across cultures and...
The Sunlight-to-Consciousness Pipeline: How Photons Become the Molecules of Awareness
There is a biochemical pipeline inside your body that converts photons — particles of light from the sun — into the very molecules that regulate consciousness, mood, sleep, dreams, and mystical experience. This pipeline is not speculative.
5-MeO-DMT: The God Molecule and the Toad
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) is the most powerful naturally occurring psychedelic known to science. A single inhaled dose of 5-15 mg produces, within seconds, a complete dissolution of ordinary consciousness — the total annihilation of the self, the boundary between observer and...
Ayahuasca: Traditional and Clinical Perspectives
Ayahuasca is a psychoactive botanical preparation originating from the Amazon basin, traditionally brewed from two primary plants: the Banisteriopsis caapi vine, which contains beta-carboline alkaloids (harmine, harmaline, tetrahydroharmine) that act as monoamine oxidase inhibitors (MAOIs), and...
Ibogaine and Addiction Interruption
Ibogaine is an indole alkaloid derived from the root bark of Tabernanthe iboga, a shrub native to the rainforests of Central West Africa, particularly Gabon and Cameroon. Among all psychedelic compounds, ibogaine occupies the most unusual pharmacological and therapeutic position: it acts...
Plant Medicine Traditions Worldwide
Long before the isolation of psilocybin, the synthesis of LSD, or the clinical trials of MDMA, human beings across every inhabited continent developed sophisticated relationships with psychoactive plants and fungi. These relationships were not recreational — they were embedded in cosmological...
Fasting and Vision Quest: Spiritual Technology of Emptying
Every spiritual tradition has discovered the same counterintuitive truth: to be filled, first become empty. To see clearly, first go into darkness.
Plant Medicine and Ceremonial Framework
In the Amazon, they do not say you "take" ayahuasca. They say ayahuasca takes you.
DMT: The Endogenous Spirit Molecule Your Brain Produces Every Day
N,N-Dimethyltryptamine — DMT — occupies a unique position in the landscape of psychedelic compounds. It is the most powerful naturally occurring psychedelic known, producing effects that depart from ordinary consciousness more radically than any other substance.
The Evolutionary Question: Why Does Biology Produce Consciousness-Altering Tryptamines?
There is a question at the heart of tryptamine biology that haunts every honest researcher who encounters it. It is not a technical question about receptors or signaling cascades.
Melatonin: The Gateway Molecule Between Waking and the Inner World
Every evening, as daylight fades and darkness rises, a molecular transformation begins in the core of your brain. In the pineal gland — a pinecone-shaped structure the size of a grain of rice, tucked between the two cerebral hemispheres — an enzyme called arylalkylamine N-acetyltransferase...
Serotonin: The Foundation Molecule of Consciousness and the Chemical Baseline of Being
You have never experienced a moment of consciousness without serotonin. Not one.
The Tryptamine Molecular Family: One Scaffold, the Entire Spectrum of Consciousness
If you could zoom in on the molecular machinery of consciousness — the actual chemical architecture that produces your mood, your sleep, your dreams, your sense of self, your capacity for mystical experience — you would find, at the center of it all, a single molecular template repeated with...